ABSTRACT
OBJECTIVE: To analyze hemodynamic and metabolic effects of saline solution infusion in the maintenance of blood volume in ischemia-reperfusion syndrome during temporary abdominal aortic occlusion in dogs. METHODS: We studied 20 dogs divided into 2 groups: the ischemia-reperfusion group (IRG, n=10) and the ischemia-reperfusion group with saline solution infusion aiming at maintaining mean pulmonary arterial wedge pressure between 10 and 20 mmHg (IRG-SS, n=10). All animals were anesthetized with sodium thiopental and maintained on spontaneous ventilation. Occlusion of the supraceliac aorta was obtained with inflation of a Fogarty catheter inserted through the femoral artery. After 60 minutes of ischemia, the balloon was deflated, and the animals were observed for another 60 minutes of reperfusion. RESULTS: IRG-SS dogs did not have hemodynamic instability after aortic unclamping, and the mean systemic blood pressure and heart rate were maintained. However, acidosis worsened, which was documented by a greater reduction of arterial pH that occurred especially due to the absence of a respiratory response to metabolic acidosis that was greater with the adoption of this procedure. CONCLUSION: Saline solution infusion to maintain blood volume avoided hemodynamic instability after aortic unclamping. This procedure, however, caused worsening in metabolic acidosis in this experimental model
Subject(s)
Animals , Male , Dogs , Blood Volume , Hemodynamics , Reperfusion Injury , Sodium Chloride , Acidosis , Aorta, Abdominal , Blood Pressure , Constriction , Heart Rate , Hydrogen-Ion Concentration , Infusions, Intra-Arterial , Reperfusion Injury , Sodium Chloride , Vascular ResistanceABSTRACT
Foram estudados 22 pacientes com diagnóstico de Síndrome da Angústia Respiratória do Adulto objetivando-se determinar as causas mais frequentes desta síndrome bem como a sua evoluçäo frente aos recursos terapêuticos disponíveis.